
冯林老师团队主要集中在多场控制的微纳米机器人方面研究。微纳米机器人难题在于如何实现高精度无污染、非接触操作,针对这些难题课题组主要取得以下成果:(1) 提出零摩擦、非接触磁场和超声悬浮耦合驱动新方法,发表在机嚣人顶级杂志IJRR,APL,JAP等;(2)实现基于微机器人的细胞克隆流水线加工方法发表在芯片上实验室Lab chip,Biomicrofluidics,IJMS,Advanced Intelligent System.等杂志;他引500多次。相关研究在国际机器人大会ICRA,IROS等获奖8次,并多次担任微纳机器人分会主席(ICRA2019,IROS2020)。2013年获得JSPS学者,2016年获得北航“卓越百人”,2018年获得“青年拔尖人才”资助,2019年获得“北京市科技新星”, 2019年负责组织申报“智能机器人”重点研发计划,并获批国家重点研发“场控微纳机器人靶向给药”重大课题资助,集合多家优势单位开展微纳机器人在肿瘤治疗方面的研究工作。研究主要集中在场控微纳载药机器人,建立靶向药物输送微纳机器人一体化制造与多场驱动技术体系,为新一代微纳米机器人制备及控制提供理论及方法支持。细胞生物学、生物制造以及再生医疗等领域中,细胞组织级的精密操作显得极为重要,比如克隆、体外受精、人工诱导多能干细胞生长成型等。传统的细胞操纵方法大多采用体积庞大的微操作机械臂,其精度低、可重复性低、价格昂贵、效率低下。因此为了解决这一几十年不变的陈旧技术,我们设计开发出了新型磁控微型机器人,应用于单细胞操作。其具有精度高、控制简单、可重复性高等优势。该微型机器人由磁性材料加工而成,封装于微流控芯片中,通过利用外界磁场的自动化控制,可以有效避免外界环境对细胞的侵染,并极大的提高了操作控制精度。 近年来参与了日本文部科学省多项重大课题研究,并在国际机器人及微纳米学会获得多个奖项。目前在微纳米系统及机械领域发表SCI/EI论文80余篇,其中于2016年2月在机器人领域最高级别的国际机器人研究杂志(International Journal of Robotics Research)上发表了关于磁控芯片机器人的创新性研究成果。 ___·主持课题与项目·__________________________________________________________ 主持或参加的主要科研项目(按时间顺序倒排) 1. 胶囊机器人系统研究,2019年-2023年,横向课题,50万 2. 光电操作设备中核心光电薄膜的研制,2020年-2021年,横向课题,100万 3. 国家重点研发计划 靶向药物输送场控微纳机器人基础研究 453万 4. 2019-nCoV快速诊断技术与互联网+AI预防控制体系, 子课题负责人 100万 5. “JCJQ计划”重点基础研究项目(GF973计划),2019-JCJQ-ZD-120-00,基于植入式芯片与光电**脊髓功能重塑技术研究,2019-12至2022-12,1200万在研,参与 6. 北京市科技新星项目 靶向给药场控微纳米机器人技术 2019.11-2021.11 50万 7. 北京市自然基金针对细胞级微纳米机器人系统研究 2017.10-2020.6 28万 8. 科技委仿生悬停平台器件研究及演示验证2017.7-2018.6 750万 9. 科技委仿生智能变色光子晶体纳驱动2017.8-2019.7 100万 10. 人才 青年拔尖人才计划 2018-2021 100万 11. 人才 卓越百人科研启动经费 2016.10-2017.12 50万 12. 人才 仿生多级结构多场效应创新团队 2017.8-2018.7 100万 13. 基础研究文部科学省Challenge of On-chip Precise Enucleation of Oocyte Using 3D 6DOF Manipulation 2013.4-2015.3 4,030,000日元 14. 基础研究文部科学省 Autonomous induction monitoring and cell measurement by ultra-high-speed operation 2013.4-2014.3 122,720,000日元 15. Nagoya Univ. GCOE High Speed Enucleation of Oocyte Using Magnetically Actuated Microrobot on a Chip 2013.4-2014.3 1,000,000日元 16. 基础研究科技振兴会 Automatic oocyte enucleation manipulation 2011.4-2013.3 2,000,000日元 17. 基础研究文部科学省 Evaluation and dynamic measurement of biomembrane transporter using on-chip 2008.4-2010.3 49,790,000日元 ___·学术期刊·_______________________________________________________________ [1] Dixiao ChenZiping YangYiming JiYuguo DaiLin FengFumihito Arai, Deformable ferrofluid-based millirobot with high motion accuracy and high output force. Applied Physics Lettersvol. 118issue 13(2021) pp: 134101 [2] Liang, S., Cao, Y., Dai, Y., Wang, F., Bai, X., Song, B., ... & Feng, L. (2021). A Versatile Optoelectronic Tweezer System for Micro-Objects Manipulation: Transportation, Patterning, Sorting, Rotating and Storage. Micromachines, 12(3), 271. [3] Chen, Y., Li, Z., Bai, X., Feng, Y., Feng, L., Zhang, D., ... & Chen, H. (2021). Reduction of Erythrocyte Fluid Adaptability Due to Cell Membrane Hardening Based on Single-Cell Analysis. BioChip Journal, 15(1), 90-99. [4] Chen, Y., Pan, Y., Feng, Y., Li, D., Man, J., Feng, L., ... & Chen, H. (2021). Role of glucose in the repair of cell membrane damage during squeeze distortion of erythrocytes in microfluidic capillaries. Lab on a Chip, 21(5), 896-903. [5] Feng, Y., Feng, L., Dai, Y., Bai, X., Zhang, C., Chen, Y., & Arai, F. A novel and controllable cell-based microrobot in real vascular network for target tumor therapy. [6] Song, B., Zhang, W., Bai, X., Feng, L., Zhang, D., & Arai, F. A novel portable cell sonoporation device based on open-source acoustofluidics. [7] Dai, Y., Feng, Y., Feng, L., Chen, Y., Bai, X., Liang, S., ... & Arai, F. Magnetized Cell-robot Propelled by Magnetic Field for Cancer Killing. [8] Bai, X., Song, B., Chen, D., Dai, Y., Feng, L., & Arai, F. Anticipating tumor metastasis by circulating tumor cells captured by acoustic microstreaming. [9] Bai, X., Bin, S., Yuguo, D., Wei, Z., Yanmin, F., Yuanyuan, C., ... & Lin, F. (2020). Parallel trapping, patterning, separating and rotating of micro-objects with various sizes and shapes using acoustic microstreaming. Sensors and Actuators A: Physical, 315, 112340. [10] Dai, Y., Liang, S., Chen, Y., Feng, Y., Chen, D., Song, B., ... & Arai, F. (2020). Untethered Octopus‐Inspired Millirobot Actuated by Regular Tetrahedron Arranged Magnetic Field. Advanced Intelligent Systems, 2(5), 1900148. [11] Bai, X., Wang, Y., Song, Z., Feng, Y., Chen, Y., Zhang, D., Feng, L. The basic properties of gold nanoparticles and their applications in tumor diagnosis and treatment, (2020) International Journal of Molecular Sciences, 21 (7), 论文编号 2480, . [12] Bai, X., Chen, D., Zhang, W., Ossian, H., Chen, Y., Feng, Y., Feng, L., Arai, F. Magnetically driven bionic millirobots with a low-delay automated actuation system for bioparticles manipulation, (2020) Micromachines, 11 (2), pp. 1-10. [13] Li, Z., Zhang, D., Wang, D., Zhang, L., Feng, L., Zhang, X. A Bioinspired Flexible Film Fabricated by Surface-Tension-Assisted Replica Molding for Dynamic Control of Unidirectional Liquid Spreading, (2019) ACS Applied Materials and Interfaces, 11 (51), pp. 48505-48511. [14] Dai, Y., Chen, D., Liang, S., Song, L., Qi, Q., Feng, L. A magnetically actuated octopus-like robot capable of moving in 3D space, (2019) IEEE International Conference on Robotics and Biomimetics, ROBIO 2019, 论文编号 8961461, pp. 2201-2206. [15] Song, B., Feng, Y., Zhou, Q., Feng, L. On-Chip Three-dimension Cell Rotation Using Whirling Flows Generated by Oscillating Asymmetrical Microstructures, (2019) IEEE International Conference on Intelligent Robots and Systems, 论文编号 8967620, pp. 678-683. [16] Feng, L., Song, B., Chen, Y., Liang, S., Dai, Y., Zhou, Q., Chen, D., Bai, X., Feng, Y., Jiang, Y., Zhang, D., Arai, F. On-chip rotational manipulation of microbeads and oocytes using acoustic microstreaming generated by oscillating asymmetrical microstructures. (2019) Biomicrofluidics, 13 (6), 论文编号 064103, . [17] Hu, H., Yang, X., Song, L., Wei, W., Peng, G., Feng, L. High Position Accuracy and 5 Degree Freedom Magnetic Driven Capsule Robot. (2019) WRC SARA 2019 - World Robot Conference Symposium on Advanced Robotics and Automation 2019, 论文编号 8931946, pp. 19-24. [18] Tovmachenko, O., Feng, L., Mousa, A.M., Ullah, Z., Masoud, M.A. A capsule-type device for soft tissue cutting using a threadless ballscrew actuator. (2019) Proceedings of MARSS 2019: 4th International Conference on Manipulation, Automation, and Robotics at Small Scales, 论文编号 8860958, . [19] Jiang, Y., Shen, D., Liu, M., Ma, Z., Zhao, P., Feng, L., Zhang, D. Fabrication of graphene/polyimide nanocomposite-based hair-like airflow sensor via direct inkjet printing and electrical breakdown. (2019) Smart Materials and Structures, 28 (6), 论文编号 065028, . [20] Feng, L., Chen, D., Zhou, Q., Song, B., Zhang, W. Cell injection microrobot development and evaluation in microfluidic chip. (2019) Proceedings - IEEE International Conference on Robotics and Automation, 2019-May, 论文编号 8793799, pp. 4831-4836. [21] Gong, D., Cai, J., Celi, N., Liu, C., Zhang, W., Feng, L., Zhang, D. Controlled propulsion of wheel-shape flaky microswimmers under rotating magnetic fields. (2019) Applied Physics Letters, 114 (12), 论文编号 123701, . [22] Hu, X., Yan, X., Gong, L., Wang, F., Xu, Y., Feng, L., Zhang, D., Jiang, Y. Improved Piezoelectric Sensing Performance of P(VDF-TrFE) Nanofibers by Utilizing BTO Nanoparticles and Penetrated Electrodes. (2019) ACS Applied Materials and Interfaces, 11 (7), pp. 7379-7386. [23] Wang, X., Cai, J., Sun, L., Zhang, S., Gong, D., Li, X., Yue, S., Feng, L., Zhang, D. Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy. (2019) ACS Applied Materials and Interfaces, 11 (5), pp. 4745-4756. [24] Chen, Y., Feng, Y., Deveaux, J.G., Masoud, M.A., Chandra, F.S., Chen, H., Zhang, D., Feng, L. Biomineralization forming process and bio-inspired nanomaterials for biomedical application: A review. (2019) Minerals, 9 (2), 论文编号 68, . [25] Jiang, Y., Ma, Z., Cao, B., Gong, L., Feng, L., Zhang, D. Development of a Tactile and Slip Sensor with a Biomimetic Structure-enhanced Sensing Mechanism. (2019) Journal of Bionic Engineering, 16 (1), pp. 47-55. [26] Song, L., Yang, X., Hu, H., Peng, G., Wei, W., Dai, Y., Feng, L. The design of 3-D space electromagnetic control system for high-precision and fast-response control of capsule robot with 5-DOF. (2019) Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics), 11745 LNAI, pp. 202-212. [27] Mousa, A., Feng, L., Dai, Y., Tovmachenko, O. Self-Driving 3-legged Crawling Prototype Capsule Robot with Orientation Controlled by External Magnetic Field. (2018) 2018 WRC Symposium on Advanced Robotics and Automation, WRC SARA 2018 - Proceeding, 论文编号 8584222, pp. 243-248. [28] Gong, D., Cai, J., Celi, N., Feng, L., Jiang, Y., Zhang, D. Bio-inspired magnetic helical microswimmers made of nickel-plated Spirulina with enhanced propulsion velocity. (2018) Journal of Magnetism and Magnetic Materials, 468, pp. 148-154. [29] Zhou, Q., Song, B., Feng, Y., Feng, L. Cell injection microrobot development and evaluation in microfluidic chip. (2018) MHS 2018 - 2018 29th International Symposium on Micro-NanoMechatronics and Human Science, 论文编号 8886994, . [30] Feng, L., Song, B., Zhang, D., Jiang, Y., Arai, F. On-chip tunable cell rotation using acoustically oscillating asymmetrical microstructures. (2018) Micromachines, 9 (11), 论文编号 596, . [31] Feng, L., Zhou, Q., Song, B., Feng, Y., Cai, J., Jiang, Y., Zhang, D. Cell injection millirobot development and evaluation in microfluidic chip. (2018) Micromachines, 9 (11), 论文编号 590, . [32] Jiang, Y., Liu, M., Yan, X., Ono, T., Feng, L., Cai, J., Zhang, D. Electrical Breakdown-Induced Tunable Piezoresistivity in Graphene/Polyimide Nanocomposites for Flexible Force Sensor Applications. (2018) Advanced Materials Technologies, 3 (8), 论文编号 1800113, . [33] Yao, G., Feng, L., Zhang, D., Jiang, X. Morphology and Mechanical Properties of Vibratory Organs in the Leaf-cutting Ant (Atta cephalotes). (2018) Journal of Bionic Engineering, 15 (4), pp. 722-730. [34] Jiang, Y., Wang, R., Feng, L., Li, J., An, Z., Zhang, D. Tunable alumina 2D photonic-crystal structures via biomineralization of peacock tail feathers. (2018) Optical Materials, 78, pp. 490-494. [35] Jiang, Y., Gong, L., Hu, X., Zhao, Y., Chen, H., Feng, L., Zhang, D. Aligned P(VDF-TrFE) nanofibers for enhanced piezoelectric directional strain sensing. (2018) Polymers, 10 (4), 论文编号 364, . [36] Feng, L., Wu, X., Jiang, Y., Zhang, D., Arai, F. Manipulating microrobots using balanced magnetic and buoyancy forces. (2018) Micromachines, 9 (2), 论文编号 50, . [37] Jiang, Y., Wang, R., Feng, L., Zhang, D. Mechanochromic response of the barbules in peacock tail feather. (2018) Optical Materials, 75, pp. 74-78. [38] Feng, L., Zhang, S., Jiang, Y., Zhang, D., Arai, F. Microrobot with passive diamagnetic levitation for microparticle manipulations. (2017) Journal of Applied Physics, 122 (24), 论文编号 243901, . [39] Feng, L., Liang, S., Zhou, X., Yang, J., Jiang, Y., Zhang, D., Arai, F. On-chip microfluid induced by oscillation of microrobot for noncontact cell transportation. (2017) Applied Physics Letters, 111 (20), 论文编号 203703, . [40] Feng, L., Di, P., Arai, F. High-precision motion of magnetic microrobot with ultrasonic levitation for 3-D rotation of single oocyte. (2016) International Journal of Robotics Research, 35 (12), pp. 1445-1458. [41] Turan, B., Sakuma, S., Feng, L., Arai, F. Automation of an on-chip cell mechanical characterization system for stiffness evaluation. (2016) 2015 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2015, 论文编号 7438327, . [42] Feng, L., Turan, B., Ningga, U., Arai, F. Three dimensional rotation of bovine oocyte by using magnetically driven on-chip robot. (2014) IEEE International Conference on Intelligent Robots and Systems, 论文编号 6943225, pp. 4668-4673. [43] Feng, L., Hagiwara, M., Ichikawa, A., Arai, F. On-Chip enucleation of bovine oocytes using microrobot-assisted flow-speed control. (2013) Micromachines, 4 (2), pp. 272-285. [44] Feng, L., Sun, Y., Ohsumi, C., Arai, F. Accurate dispensing system for single oocytes using air ejection, (2013) Biomicrofluidics, 7 (5), 论文编号 054113, . [45] Feng, L., Ichikawa, A., Arai, F., Hagiwara, M. Continuous enucleation of bovine oocyte by microrobot with local flow distribution control, (2012) 2012 International Conference on Manipulation, Manufacturing and Measurement on the Nanoscale, 3M-NANO 2012 - Conference Proceedings, 论文编号 6472969, pp. 59-64. [46] Feng, L., Hagiwara, M., Ichikawa, A., Sun, Y.L., Arai, F. High-speed production and dispensing of enucleated oocyte by microrobot on a chip, (2012) 2012 International Symposium on Micro-NanoMechatronics and Human Science, MHS 2012, 论文编号 6492464, pp. 111-115. [47] Feng, L., Hagiwara, M., Ichikawa, A., Kawahara, T., Arai, F. Smooth enucleation of bovine oocyte by microrobot with local flow speed control in microchannel, (2012) IEEE International Conference on Intelligent Robots and Systems, 论文编号 6386112, pp. 944-949. [48] Feng, L., Hagiwara, M., Ichikawa, A., Arai, F. On-Chip continuous enucleation by hydraulic force control using magnetically actuated microrobot, (2012) Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2012, pp. 1270-1272. [49] Feng, L., Kawahara, T., Yamanishi, Y., Hagiwara, M., Kosuge, K., Arai, F. On-demand and size-controlled production of droplets by magnetically driven microtool, (2012) Journal of Robotics and Mechatronics, 24 (1), pp. 133-140. [50] Hagiwara, M., Kawahara, T., Feng, L., Yamanishi, Y., Arai, F. On-chip enucleation of oocyte by magnetically driven microtools with ultrasonic vibration, (2011) Proceedings - IEEE International Conference on Robotics and Automation, 论文编号 5979930, pp. 2680-2685. [51] Hagiwara, M., Kawahara, T., Feng, L., Yamanishi, Y., Arai, F. High performance magnetically driven microtools with ultrasonic vibration for biomedical innovations, (2011) Proceedings - IEEE International Conference on Robotics and Automation, 论文编号 5980470, pp. 3453-3454. [52] Uvet, H., Feng, L., Ohashi, S., Hagiwara, M., Kawahara, T., Yamanishi, Y., Arai, F. On-chip single particle loading and dispensing, (2011) Proceedings - IEEE International Conference on Robotics and Automation, 论文编号 5980449, pp. 3151-3156. [53] Feng, L., Hagiwara, M., Uvet, H., Yamanish, Y., Kawahara, T., Kosuge, K., Arai, F. High-speed delivery of microbeads in microchannel using magnetically driven microtool, (2011) 2011 16th International Solid-State Sensors, Actuators and Microsystems Conference, TRANSDUCERS'11, 论文编号 5969431, pp. 1312-1315. [54] Hagiwara, M., Kawahara, T., Yamanishi, Y., Masuda, T., Feng, L., Arai, F. On-chip magnetically actuated robot with ultrasonic vibration for single cell manipulations,(2011) Lab on a Chip, 11 (12), pp. 2049-2054. [55] Hagiwara, M., Kawahara, T., Feng, L., Yamanishi, Y., Arai, F. On-chip dual-arm microrobot driven by permanent magnets for high speed cell enucleation, (2011) Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 论文编号 5734393, pp. 189-192. [56] Feng, L., Huseyin, U., Kawahara, T., Hagiwara, M., Yamanish, Y., Arai, F. On-chip high-speed and on-demand single microbeads loading, (2011) 2011 Int. Symp. on Micro-NanoMechatronics and Human Science, Symp. on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "Hyper Bio Assembler for 3D Cellular System Innovation", 论文编号 6102195, pp. 291-296. [57] Kawahara, T., Hirano, T., Feng, L., Uvet, H., Hagiwara, M., Yamanishi, Y., Arai, F. High-speed single cell dispensing system (2011) 2011 Int. Symp. on Micro-NanoMechatronics and Human Science, Symp. on "COE for Education and Research of Micro-Nano Mechatronics", Symposium on "Hyper Bio Assembler for 3D Cellular System Innovation", 论文编号 6102235, pp. 472-474. [58] Hagiwara, M., Kawahara, T., Feng, L., Yamanish, Y., Arai, F. High precision magnetically driven microtools with ultrasonic vibration for enucleation of oocytes (2010) 2010 International Symposium on Micro-NanoMechatronics and Human Science: From Micro and Nano Scale Systems to Robotics and Mechatronics Systems, MHS 2010, Micro-Nano GCOE 2010, Bio-Manipulation 2010, 论文编号 5669580, pp. 47-52. [59] Yamanishi, Y., Feng, L., Arai, F. On-demand production of emulsion droplets over a wide range of sizes (2010) Advanced Robotics, 24 (14), pp. 2005-2018. 日本国内 [1] L.Feng, Y.Yamanishi, T.Kawahara, M.Hagiwara, K.Kosuge, and F.Arai, “Robot-on-a-chip Part 1: On-chip Generation of Droplets and Size Control,” in 日本機械学会ロボティクス・メカトロニクス講演会, 2010, pp. 1P1–U04. [2] 萩原将也, 川原知洋, 馮林, 山西陽子, and 新井史人, “双腕マイクロアームの高精度な非接触操作,” in 第22回化学とマイクロ・ナノシステム研究会, 2010, p. P.26. [3] 萩原将也, 川原知洋, 馮林, 山西陽子, and 新井史人, “マイクロ流体チップ内で超高速動作する双腕マイクロロボットによる細胞操作・切断,” in 第28回日本ロボット学会学術講演会, 2010, pp. 2M2–7. [4] L.Feng, Y.Yamanishi, T.Kawahara, M.Hagiwara, K.Kosuge, and F.Arai, “Generation of Droplet with Feedback Control on a Chip,” in 第22回化学とマイクロ・ナノシステム研究会, 2010, p. P.25. [5] L.Feng, Y.Yamanishi, T.Kawahara, M.Hagiwara, K.Kosuge, and F.Arai, “On-chip Size-controllable Droplet Generation,” in 第11回 計測自動制御学会 システムインテグレーション部門講演会, 2011, pp. 3I2–3. [6] L.Feng, Y.Yamanishi, T.Kawahara, M.Hagiwara, K.Kosuge, and F.Arai, “On-chip Smooth Enucleation by Hydraulic Force Control Using Magnetically Driven Microtool,” in ロボティクス・メカトロニクス講演会, 2012, pp. 1P1–U04. [7] 平野 達彦, 川原 知洋, ウベット フセイン, 馮林, 新井 史人, “ローディング機構を有する単一細胞分注システム” in第12回 計測自動制御学会 システムインテグレーション部門講演会, 2012, pp. 1P1–U04 |