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学术报告:Development of Microdevices for Enhancing Cell Therapy

作者: 发布: 2018-07-11

 Development of Microdevices for Enhancing Cell Therapy

 

报告人: Jingjiao Guan, Ph.D., Florida State University

报告时间:2018712 930 - 1200

报告地点:北航新主楼A849

邀请单位:机械工程及自动化学院

 

报告人简介:


Dr. Jingjiao Guan is an Associate Professor in the Department of Chemical and Biomedical Engineering, the Florida Agricultural & Mechanical University-Florida State University (FAMU-FSU) College of Engineering. He received PhD in Biomedical Engineering from The Ohio State University (OSU) in 2005 and then worked as a postdoctoral researcher and later as a research associate in the United States (U.S.) National Science Foundation-funded Nanoscale Science and Engineering Center for Affordable Nanoengineering of Polymeric Biomedical Devices at OSU. He joined FSU in 2008 as a tenure-track Assistant Professor and was promoted to an Associated Professor with tenure in 2014. Dr. Guan’s main research interest is micro/nanofabrication for biomedical applications. He and co-workers have developed novel fabrication techniques for producing various nanostructures including nanoparticles, nanostrands, nanowires, and nanochannels. In recent years, his group has been focusing on developing micrometer-sized devices for cell-mediated drug delivery application. Dr. Guan has published 43 research articles in peer-reviewed journals such as Proceedings of National Academy of Science, U. S. A., Nature Nanotechnology, and Advanced Materials. He has also published four book chapters and hold two U.S. patents. His research has been supported by Florida Department of Health, U.S. National Science Foundation and National Institutes of Health.

 

报告内容:

Cell therapy, which features the use of live cells as therapeutic agents for treating diseases, is progressing rapidly in recent years and holds potential to revolutionize treatment of devastating diseases such as cancer. Conventional cell therapy relies on modifying therapeutic cells with biological approaches, consequently its capacity is constricted within the biological realm. On the other hand, micrometer-sized devices termed microdevices can be made with biological materials as well as synthetic materials with many unparcelled properties compared to the biological materials. My lab focuses on developing novel microdevices that can be attached to therapeutic cells and enhance the performance of the cells. We have established a methodology for fabricating microdevices with a variety of materials such as polyelectrolytes, enzymes, nanoparticles, and carbon nanotubes, and a simple yet effective method for preparing cell-microdevice complexes. We have also investigated the use of the microdevices for tracking therapeutic cells or as carriers for therapeutic enzymes, and studied the effect of the microdevices on the human stem cells. This talk will provide an overview of our research in this area with an emphasis on the recent results.