 小空间尺度的机器人技术和自动化的新兴领域提出了新的科学挑战，并有望在生物学、医学、工业、微纳米技术以及环境等应用领域取得革命性进展。在微观和纳米尺度上的现象通常与宏观上的现象有显著的不同，这对机器人的策略、算法、操作、移动和控制的软件和硬件有很强的影响。细胞、生物分子和生命过程都具有纳米和微尺度的特征。纳米和微尺度上的人工设备和系统将能够与生物设备和系统密切互动，并有望产生新的科学认识和用于疾病检测和治疗等基本任务的新工具。此外，对微、纳米级器件的可靠、自动操作也是组装MEMS、NEMS等各种新型器件的一大挑战。 细胞生物学、生物制造以及再生医疗等领域中，细胞组织级的精密操作显得极为重要，比如克隆、体外受精、人工诱导多能干细胞生长成型等。传统的细胞操纵方法大多采用体积庞大的微操作机械臂，其精度低、可重复性低、价格昂贵、效率低下。因此为了解决这一几十年不变的陈旧技术，我们设计开发出了新型磁控微型机器人，应用于单细胞操作。其具有精度高、控制简单、可重复性高等优势。该微型机器人由磁性材料加工而成，封装于微流控芯片中，通过利用外界磁场的自动化控制，可以有效避免外界环境对细胞的侵染，并极大的提高了操作控制精度。 创新点 1. 提出零摩擦非接触微空间驱动新方法，发表在机器人顶级杂志（IJRR，JAP） 2. 实现细胞级非接触多自由度精密控制，发表在芯片上实验室（Lab chip） 3. 实现了细胞级微手术操作，发表在生物微流体、微机械（APL, Biomicrofluidics） 近年来参与了日本文部科学省多项重大课题研究，并在国际机器人及微纳米学会获得多个奖项。目前在微纳米系统及机械领域发表论文60余篇，其中于2016年2月在机器人领域最高级别的国际机器人研究杂志(International Journal of Robotics Research)上发表了关于磁控芯片机器人的创新性研究成果。 ___·主持课题与项目·__________________________________________________________ 主持或参加的主要科研项目（按时间顺序倒排） 1. 科技部重点研发计划靶向药物输送场控微纳机器人基础研究1000万 2. 北京市科技新星项目靶向给药场控微纳米机器人技术2019.11-2021.11 50万 3. 北京市自然基金针对细胞级微纳米机器人系统研究 2017.10-2020.6 28万 4. 科技委仿生悬停平台器件研究及演示验证2017.7-2018.6 750万 5. 科技委仿生智能变色光子晶体纳驱动2017.8-2019.7 100万 6. 人才卓越百人科研启动经费 2016.10-2017.12 50万 7. 人才仿生多级结构多场效应创新团队 2017.8-2018.7 100万 8. 基础研究文部科学省Challenge of On-chip Precise Enucleation of Oocyte Using 3D 6DOF Manipulation 2013.4-2015.3 4,030,000日元 9. 基础研究文部科学省 Autonomous induction monitoring and cell measurement by ultra-high-speed operation 2013.4-2014.3 122,720,000日元 10. Nagoya Univ. GCOE High Speed Enucleation of Oocyte Using Magnetically Actuated Microrobot on a Chip 2013.4-2014.3 1,000,000日元 11. 基础研究科技振兴会 Automatic oocyte enucleation manipulation 2011.4-2013.3 2,000,000日元 12. 基础研究文部科学省 Evaluation and dynamic measurement of biomembrane transporter using on-chip 2008.4-2010.3 49,790,000日元 ___·学术期刊·_______________________________________________________________ [1] Feng, L., Song, B., Chen, Y., Liang, S., Dai, Y., Zhou, Q., Chen, D., Bai, X., Feng, Y., Jiang, Y., Zhang, D., Arai, F. On-chip rotational manipulation of microbeads and oocytes using acoustic microstreaming generated by oscillating asymmetrical microstructures(2019) Biomicrofluidics, 13 (6), 论文编号 064103, . [2] Tovmachenko, O., Feng, L., Mousa, A.M., Ullah, Z., Masoud, M.A.A capsule-type device for soft tissue cutting using a threadless ball screw actuator(2019) Proceedings of MARSS 2019: 4th International Conference on Manipulation, Automation, and Robotics at Small Scales, 论文编号 8860958, . [3] Jiang, Y., Shen, D., Liu, M., Ma, Z., Zhao, P., Feng, L., Zhang, D.Fabrication of graphene/polyimide nanocomposite-based hair-like airflow sensor via direct inkjet printing and electrical breakdown (2019) Smart Materials and Structures, 28 (6), 论文编号 065028, . [4] Feng, L., Chen, D., Zhou, Q., Song, B., Zhang, W.Cell injection microrobot development and evaluation in microfluidic chip(2019) Proceedings - IEEE International Conference on Robotics and Automation, 2019-May, 论文编号 8793799, pp. 4831-4836. [5] Gong, D., Cai, J., Celi, N., Liu, C., Zhang, W., Feng, L., Zhang, Controlled propulsion of wheel-shape flaky microswimmers under rotating magnetic fields(2019) Applied Physics Letters, 114 (12), 论文编号 123701, [6] Hu, X., Yan, X., Gong, L., Wang, F., Xu, Y., Feng, L., Zhang, D., Jiang, Y. Improved Piezoelectric Sensing Performance of P(VDF-TrFE) Nanofibers by Utilizing BTO Nanoparticles and Penetrated Electrodes(2019) ACS Applied Materials and Interfaces, 11 (7), pp. 7379-7386. [7] Wang, X., Cai, J., Sun, L., Zhang, S., Gong, D., Li, X., Yue, S., Feng, L., Zhang, D. Facile Fabrication of Magnetic Microrobots Based on Spirulina Templates for Targeted Delivery and Synergistic Chemo-Photothermal Therapy(2019) ACS Applied Materials and Interfaces, 11 (5), pp. 4745-4756. [8] Chen, Y., Feng, Y., Deveaux, J.G., Masoud, M.A., Chandra, F.S., Chen, H., Zhang, D., Feng, L. Biomineralization forming process and bio-inspired nanomaterials for biomedical application: A review (2019) Minerals, 9 (2), 论文编号 68, . [9] Jiang, Y., Ma, Z., Cao, B., Gong, L., Feng, L., Zhang, D. Development of a Tactile and Slip Sensor with a Biomimetic Structure-enhanced Sensing Mechanism(2019) Journal of Bionic Engineering, 16 (1), pp. 47-55. 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